We are all mindful of the fact that slimming is actually a mega-dollar industry. With millions, otherwise billions of people of all ages struggling to lose weight, and also few pharmaceutically effective medications accessible to assist them, the desperate public will literally clutch at straws.
Every week sees the launch of the new “miracle” slimming pill or potion plus a “surefire” diet bound to help believers shed kilos like magic.
Recently doctor oz.com diet had become the flavour of the season. In the event you search the net for information on this exotic fruit extract you will end up assured this is finally the miracle most of us have been waiting for, that can produce dramatic weight loss. Endorsements by various TV personalities along with other luminaries have included with the allure of Garcinia cambogia slimming products.
As outlined by a newly released local study through the Tshwane University of Technology (TUT) “this small fruit, reminiscent of a pumpkin in looks, is presently most popularly used and widely advertised like a weight-loss supplement”.
The comprehensive overview from TUT suggests that research has shown that “the extracts as well as (-)-hydroxycitric acid (HCA), a main organic acid part of the fruit rind, exhibited anti-obesity activity”. In addition, it regulates the serotonin levels associated with satiety, leading to reduced intake of food.
“Based on clinical trial reports, Garcinia extracts were beneficial to obese individuals on many occasions. Moreover, studies around the toxicity and observations during clinical studies indicate that Garcinia is safe to use. Many of the negative reports are already linked to times when multi ingredient formulations were consumed and also the effect could not really associated with a particular ingredient.”
The study does, however, caution against a rise in serotonin, specially in those who take medicines which are already increasing serotonin levels, including SSRIs. Research in to these effects has not been conducted.
“Moreover, regulatory authorities should provide and enforce legislation requiring the compulsory basic safety illustration showing supplements pre-marketing and develop post-marketing surveillance systems,” the research concluded.
Dr Ingrid van Heerden, a registered dietitian, is of opinion that we must be cautious of where can you buy garcinia cambogia extract, because it has not yet undergone rigorous testing. What follows is reviewed information from her pen, including her final verdict:
Often, once an individual who wants, or needs to shed weight, is hooked on the promise of a slim, sexy figure, they can be sucked into the deception. When the drops, wafers or powders don’t work, well then its the fault of the user who failed to abide by one or some other often impossible instruction including “stick to some 500 kcal/day diet” or “drink 5 litres of water a day”, never that from the diet pill.
When eventually science and legislation catch up with the makers, they calmly take product A from the market, change their formulation slightly, modify the name to product B, and after that blithely sell product B utilizing the same advertising gambits as before, raking in the money and pulling the wool over everyone’s eyes yet again.
In line with the ever-changing slimming product ranges, there are what one can call “ingredients of the season” (sometimes an ingredient can last for only 3 to 6 months, however, some have longer life spans, after which of course some are resurrected every two to three years).
We certainly have had apple cider vinegar (which has made many a comeback through the years), green tea leaf (which has earned some merit in scientific research), hoodia (which just will not have the ability to make the research results that can make it a front-runner), willow bark (or salicylic acid which will work for pains and aches but not as efficacious for slimming), and traditional caffeine (that has a diuretic effect thus helping you to shed weight till you replenish this type of water within your body, plus a stimulant effect when taken in large quantities that may be potentially dangerous), to call but several.
While it is perfectly likely that more extensive and well controlled scientific research will reveal that the extract of Garcinia cambogia that contains a chemical called hydroxycitric acid (HCA) will assist weight reduction, our company is presently not even sure how this tamarind or brindall berry or brindleberry or Garcinia gummi-gutta works, what side-effects it may or may not have and what dosage is needed to achieve really significant weight reduction.
Nevertheless I hear you say: “For once we have a number of scientific tests which were conducted with Garcinia cambogia, so what’s the issue?”
Well some of the studies did not show any weight loss differences between patients who took Garcinia pills and people who took dummy pills, while other studies did show variations in weight loss with all the subjects taking pills containing Garcinia losing a little more weight than others that did not (Marquez et al, 2012).
Many of these weight reduction differences were not quite exciting either, and then we can’t say beyond doubt that Garcinia cambogia does promote fat loss. It also seems likely that this is not the wonder pill it is actually made over to be.
Moreover, a lot of the studies conducted to date have been flawed (Critchley, 2013) . What it means is perfect for example that in one study the control and experimental subjects were not well matched (i.e. they was without a similar starting weight, age, percentage of extra fat etc.), during other studies too few subjects were utilized for the leads to be significant.
For your results of studies to become plausible one must compare “apples with apples” (i.e. well-matched subjects and controls) and you need not only a number of subjects to create the same result.
In the positive side, we are able to say that there is certainly some evidence that Garcinia cambogia products may aid weight-loss over a duration of 12 weeks. No research has been conducted for extended periods as yet (Marquez et al, 2012), which is thought to be a drawback.
Addititionally there is currently a disagreement regarding the safety of pills containing Garcinia cambogia – one group of researchers slates the pills as dangerous and hepatotoxic (causing liver damage) (Kim et al, 2013), while another group refutes this (Clouatre & Preuss, 2013). Marquez with his fantastic coworkers (2012) claim that “at the doses usually administered, no differences are already reported regarding side effects or adverse events (those studied) in humans between individuals treated with G. cambogia and controls.”
Ano Lob (2009), a public health consultant in america has published a warning regarding the hepatotoxicity of a fat loss product called “Hydroxycut”, which contains Garcinia cambogia. The writer collected case reports of patients who developed liver toxicity associated with the aforementioned fat loss product.
Evidently approximately one million units of the hydroxycitric acid product are sold each year in the us. The patients who developed hepatotoxicity reported signs of fatigue, nausea, vomiting, cramps, fever, chills, abdominal pain, and jaundice.
While the number of hepatotoxicity cases reported were not many, Lob indicates that monitoring of adverse events linked to vitamin supplements such as these weight loss products is woefully inadequate in the us (as is the situation in lots of other countries, including South Africa), with all the FDA only receiving about 1% of those negative reports.
According to Lob (2009), the Poison Control Centres in the united states are more inclined to receive reports of adverse events associated with health supplements however they are not equipped to coordinate such findings.
He cites the truly sobering illustration of a product called “Metabolife 356″ which was sold as a diet supplement in the united states. Lob’s states how the manufacturers received 14 000 reports during a period of 5 years that documented “serious adverse events related to their ephedra-containing product” which dexrpky17 cardiac arrest, strokes, convulsions and fatalities.
The makers did not inform the FDA or any other US government authority of the reports. As astounding since this might sound, manufacturers of health supplements usually are not required to meet any one of the specifications that are strictly enforced when it comes to food and pharmaceutical products (medicines), so they can take advantage of this “ethical loophole” to not publish reports of negative and harmful events.
Eventually these events arrived at light and ephedra-containing products for slimming and other uses were banned in the us.
The implication contain in Lob’s warning is the fact HCA or Garcinia cambogia extract will also be potentially toxic unless sufficient, reliable evidence for the contrary is manufactured available.
At the present moment, we have no idea enough about slimming products which contain garcinia cambogia extract side effects to freely recommend its use. I often are in agreement with Astell and coworkers (2013) who conducted a systematic review of double blind randomised controlled numerous studies to assess evidence seen on the efficacy of current nutritional supplements employed to control appetite or weight.
These authors concluded that “According for the finding from this systematic review, evidence is just not convincing in demonstrating that a majority of vitamin supplements used as appetite suppressants for weight-loss in the treatment of obesity work well and safe.”
While we wait around for more extensive and conclusive evidence obtained with larger variety of well-matched test subjects treated for extended periods together with the “gold standard” of double blind randomised controlled clinical studies, rather stay away from any weight-loss supplement that is not tested thoroughly.